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Protein Coding Gene : Bcr BCR activator of RhoGEF and GTPase

Primary Identifier  MGI:88141 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  110279
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; negative regulation of macrophage migration; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase).
PHENOTYPE: Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia. [provided by MGI curators]
  • synonyms:
  • mKIAA3017,
  • AI561783,
  • MGI:2143694,
  • expressed sequence AI853148,
  • AI853148,
  • BCR activator of RhoGEF and GTPase,
  • MGD-MRK-1530,
  • breakpoint cluster region,
  • MGI:1918508,
  • RIKEN cDNA 5133400C09 gene,
  • MGI:2143646,
  • expressed sequence AI561783,
  • Bcr,
  • 5133400C09Rik

Features --> Cross References

Genome

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0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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0 Driver For