Primary Identifier | IPR035673 | Type | Domain |
Short Name | ERdj5_TRX_N |
description | ERdj5, also known as Dnajc10 (DnaJ homologue subfamily C member 10), JPDI or macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains []. This entry comprises the first TRX domain of ERdj5 located after the DnaJ domain at the N-terminal half of the protein. ERdj5 is a ubiquitous proteinlocalized in the endoplasmic reticulum (ER) and is abundant in secretory cells. It's transcription is induced during ER stress []. It interacts with BiP through its DnaJ domain in an ATP-dependent manner. BiP, an ER-resident member of the Hsp70 chaperone family, functions in ER-associated degradation and protein translocation []. |