| Primary Identifier | IPR035802 | Type | Domain |
| Short Name | ENTH/VHS_tepsin |
| description | Tepsin (also known as the product of the ENTHD2 or AP4AT gene) is an AP-4 accessory protein. It binds to the beta4-ear domain of AP-4, and is recruited to the trans-Golgi network (TGN) in manner dependent on this interaction []. This is the ENTH/VHS domain in tepsin and in A. thaliana protein At3g16270 [].Unlike the other members of the ENTH/ANTH/VHS superfamily, the tepsin ENTH domain lacks helix0, helix8, and a lipid binding pocket. Loss of helix0 precludes formation of a lipid binding pocket and explains why tepsin ENTH domain cannot interact directly with phosphoinositide head groups []. |
