| Primary Identifier | MGI:1861589 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Wo |
| Inheritance Mode | Dominant | Strain of Origin | (C57BL/6J x DBA/2J)F1 |
| Is Recombinase | false | Is Wild Type | false |
| description | This transgenic neurological mutation disrupts inner ear development. Mutant mice display a dominant behavioral phenotype of circling, hyperactivity, and head-tossing, like waltzer class mutants. Viability of homozygotes is reduced. Both structural and neural components of the inner ear were disrupted due to aberrant development (J:11245). |
| molecularNote | The inserted transgenic construct contains a human vasopressin promoter region adjoined to a 1.9 kb fragment of a v-src gene from the Schmidt-Ruppin A strain of RSV. Southern blot analysis indicated that a single copy of the construct integrated into the genome of founder mice. Mapping data indicated that a complex rearrangement involving 6.3 cM of flanking genomic DNA had taken place at the transgene insertion site. The DNA was not deleted nor simply inverted and involved at least 4 breakpoints. |
