| First Author | Salmond RJ | Year | 2015 |
| Journal | Cell Cycle | Volume | 14 |
| Issue | 5 | Pages | 705-11 |
| PubMed ID | 25715232 | Mgi Jnum | J:333635 |
| Mgi Id | MGI:6783091 | Doi | 10.1080/15384101.2015.1007018 |
| Citation | Salmond RJ, et al. (2015) Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis. Cell Cycle 14(5):705-11 |
| abstractText | The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene are important risk alleles in human autoimmune diseases. We recently reported that a key physiological function of PTPN22 was to prevent naive T cell activation and effector cell responses in response to low affinity antigens. PTPN22 also has a more general role in limiting T cell receptor-induced proliferation. Here we present new data emphasizing this dual function for PTPN22 in T cells. Furthermore, we show that T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases. We discuss the implication of these findings for our understanding of the roles of PTPN22 in regulating T cell responses and in autoimmunity. |
