| First Author | Wesche H | Year | 1996 |
| Journal | FEBS Lett | Volume | 391 |
| Issue | 1-2 | Pages | 104-8 |
| PubMed ID | 8706893 | Mgi Jnum | J:35304 |
| Mgi Id | MGI:82754 | Doi | 10.1016/0014-5793(96)00713-2 |
| Citation | Wesche H, et al. (1996) Co-expression of mRNA for type I and type II interleukin-1 receptors and the IL-1 receptor accessory protein correlates to IL-1 responsiveness. FEBS Lett 391(1-2):104-8 |
| abstractText | Three cell surface molecules participate in Interleukin-1 (IL-1) binding and signal generation, the two distinct types of receptors (type I IL-1R and type II IL-1R) and the IL-1 receptor accessory protein (IL-1RAcP). Low surface expression hampers the detection of all three components on a protein level in most cell types, thus the highly sensitive RT-PCR was used to analyse the mRNA expression in a panel of 18 murine cell types of different hemopoietic lineages and fibroblasts. The transcription of both types of IL-1 receptors was detected in all cell lines tested. In most cell lines the IL-1RAcP was co-expressed with the IL-1 receptors, and only these lines responded to IL-1. However, in three cell lines no mRNA for the IL-1RAcP could be detected, and these cells did not respond to IL-1. These results suggest that the expression of the IL-1RAcP correlates with IL-1 responsiveness and they point to a pivotal role for the IL-1RAcP in IL-1 signal generation. |
