| Primary Identifier | MGI:1338871 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12234 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables beta-catenin binding activity; protein phosphorylated amino acid binding activity; and ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including mammary gland epithelium development; protein K48-linked ubiquitination; and regulation of canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system; and respiratory system. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase). PHENOTYPE: Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
