First Author | Kobayashi T | Year | 1996 |
Journal | Genomics | Volume | 37 |
Issue | 3 | Pages | 390-4 |
PubMed ID | 8938453 | Mgi Jnum | J:36739 |
Mgi Id | MGI:84165 | Doi | 10.1006/geno.1996.0575 |
Citation | Kobayashi T, et al. (1996) Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene. Genomics 37(3):390-4 |
abstractText | A mouse histamine H2 receptor (H2R) gene was isolated from a mouse ES cell genomic DNA library. The gene encoded a 358-amino-acid protein and displayed a 95% homology with the rat histamine H2 receptor at the amino acid level. It had features characteristic of other G-protein-coupled receptors. Reverse transcriptase-polymerase chain reaction analysis of total RNA prepared from mouse tissues showed that the gene was highly expressed in stomach and moderately in brain and heart. A weak expression was also detected in liver. An interspecific backcross analysis revealed that the mouse H2R gene, designated Hrh2, was located in the central region of chromosome 13. |