| First Author | Simpson EH | Year | 1999 |
| Journal | Genomics | Volume | 59 |
| Issue | 1 | Pages | 102-4 |
| PubMed ID | 10395806 | Mgi Jnum | J:56256 |
| Mgi Id | MGI:1340703 | Doi | 10.1006/geno.1999.5853 |
| Citation | Simpson EH, et al. (1999) Identification, sequence, and mapping of the mouse multiple PDZ domain protein gene, Mpdz. Genomics 59(1):102-4 |
| abstractText | The PDZ domain gained its name from the three proteins that were first seen to have homology by virtue of these domains, the mammalian postsynaptic density protein, PSD- 95, the Drosophila discs-large septate junction protein, DLG, and the mammalian epithelial tight-junction protein zona occludens, ZO-1. Over 50 PDZ domain-containing genes have been recognized so far from almost any organism subjected to sequencing, including mammals, nematodes, yeast, plants, and bacteria. The domain consists of an approximately 90-amino-acid-residue unit, which is often repeated in the protein. The majority of residues form a conserved spatial structure while a few amino acids in critical positions confer protein binding specificity. A subgroup of PDZ domains have been shown to recognize a short carboxy-terminal amino acid motif, T/SXV (Ser/Thr-X- Val-COO-), where X is any amino acid. We have identified and completely sequenced a gene, Mpdz, that encodes a mouse protein containing 13 such domains. We have also mapped the gene to a series of overlapping deletions on mouse chromosome 4 and can therefore determine that its function is not essential for embryonic development or neonatal survival. (C) 1999 Academic Press. |
