| First Author | Johnson CM | Year | 1997 |
| Journal | Tuber Lung Dis | Volume | 78 |
| Issue | 5-6 | Pages | 257-61 |
| PubMed ID | 10209680 | Mgi Jnum | J:55984 |
| Mgi Id | MGI:1339849 | Doi | 10.1016/s0962-8479(97)90006-x |
| Citation | Johnson CM, et al. (1997) Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. Tuber Lung Dis 78(5-6):257-61 |
| abstractText | OBJECTIVE: Use gene disrupted mice to examine the possible role of secretory antibody on resistance to re-exposure to pulmonary tuberculosis. DESIGN: Mice deficient in B cells due to targeted gene disruption were infected by aerosol exposure with Mycobacterium tuberculosis. A further set were identically exposed then given isoniazid to clear the infection and establish a state of memory immunity. RESULTS: Control of the aerosol infection and generation of gamma interferon proceeded in a similar manner in both naive and memory immune mice, regardless of B cell deficiency. CONCLUSIONS: The absence of antibody responses did not affect the course of infection, thus confirming the classical literature that antibody plays no significant protective role. |
