| First Author | Amit I | Year | 2004 |
| Journal | Genes Dev | Volume | 18 |
| Issue | 14 | Pages | 1737-52 |
| PubMed ID | 15256501 | Mgi Jnum | J:150398 |
| Mgi Id | MGI:3850622 | Doi | 10.1101/gad.294904 |
| Citation | Amit I, et al. (2004) Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. Genes Dev 18(14):1737-52 |
| abstractText | The tumor suppressor gene 101 (tsg101) regulates vesicular trafficking processes in yeast and mammals. We report a novel protein, Tal (Tsg101-associated ligase), whose RING finger is necessary for multiple monoubiquitylation of Tsg101. Bivalent binding of Tsg101 to a tandem tetrapeptide motif (PTAP) and to a central region of Tal is essential for Tal-mediated ubiquitylation of Tsg101. By studying endocytosis of the epidermal growth factor receptor and egress of the human immunodeficiency virus, we conclude that Tal regulates a Tsg101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane. |
