| First Author | Ma JT | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 200 |
| Issue | 3 | Pages | 1742-7 |
| PubMed ID | 7910456 | Mgi Jnum | J:18078 |
| Mgi Id | MGI:66097 | Doi | 10.1006/bbrc.1994.1654 |
| Citation | Ma JT, et al. (1994) Muscle homeodomain protein MHox inhibits ternary complex formation at the c-fos serum response element. Biochem Biophys Res Commun 200(3):1742-7 |
| abstractText | The Serum Response Element in the c-fos promoter is the target of growth factor-regulated signal transduction pathways. The ternary complex of Serum Response Element-binding protein Serum Response Factor and its accessory protein Ternary Complex Factor are important for transcriptional stimulation of the c-fos promoter in fibroblasts. However, this promoter is repressed in differentiating muscle cells. We discovered that MHox, a muscle homeodomain protein, was capable of inhibiting formation of the ternary complex by direct physical interaction between MHox and Serum Response Factor accessory protein-1 (SAP-1), one member of the Ternary Complex Factor family of proteins. Furthermore, exogenous MHox protein inhibited serum-inducibility of a Serum Response Element-dependent reporter gene in permeabilized fibroblasts. Taken together, these results imply that MHox is involved in blocking mitogenic signals during myogenesis. |
