| First Author | Tanaka M | Year | 1997 |
| Journal | FEBS Lett | Volume | 402 |
| Issue | 2-3 | Pages | 219-22 |
| PubMed ID | 9037199 | Mgi Jnum | J:38332 |
| Mgi Id | MGI:85707 | Doi | 10.1016/s0014-5793(96)01537-2 |
| Citation | Tanaka M, et al. (1997) Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product. FEBS Lett 402(2-3):219-22 |
| abstractText | We have isolated a new MT-MMP related gene of 3.3 kb from a mouse lung cDNA library using a human MT1-MMP cDNA as a probe. The deduced protein sequence shows 87% homology to human MT2-MMP and 52, 50 and 29% to MT1-MMP, MT3-MMP and MT4-MMP, respectively. Thus the gene is thought to be a mouse homologue of human MT2-MMP. A monoclonal antibody raised against a synthetic peptide recognized mouse MT2-MMP as a 70 kDa protein. Like MT1- and MT3-MMPs, mouse MT2-MMP caused activation of progelatinase A upon co-transfection into COS-1 cells. |
