| Primary Identifier | MGI:1344401 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 108089 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in pattern recognition receptor signaling pathway; protein K6-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ubiquitin ligase complex. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human RNF144A (ring finger protein 144A). PHENOTYPE: Homozygous null mice show increased susceptibility to HSV-1 infection and impaired DNA virus or exogenous cytosolic-DNA triggered innate immune responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
