| First Author | Senoo N | Year | 2015 |
| Journal | J Lipid Res | Volume | 56 |
| Issue | 12 | Pages | 2286-96 |
| PubMed ID | 26438561 | Mgi Jnum | J:227710 |
| Mgi Id | MGI:5702517 | Doi | 10.1194/jlr.M060533 |
| Citation | Senoo N, et al. (2015) PGC-1alpha-mediated changes in phospholipid profiles of exercise-trained skeletal muscle. J Lipid Res 56(12):2286-96 |
| abstractText | Exercise training influences phospholipid fatty acid composition in skeletal muscle and these changes are associated with physiological phenotypes; however, the molecular mechanism of this influence on compositional changes is poorly understood. Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), a nuclear receptor coactivator, promotes mitochondrial biogenesis, the fiber-type switch to oxidative fibers, and angiogenesis in skeletal muscle. Because exercise training induces these adaptations, together with increased PGC-1alpha, PGC-1alpha may contribute to the exercise-mediated change in phospholipid fatty acid composition. To determine the role of PGC-1alpha, we performed lipidomic analyses of skeletal muscle from genetically modified mice that overexpress PGC-1alpha in skeletal muscle or that carry KO alleles of PGC-1alpha. We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6). We also found that exercise training increased PC (18:0/22:6) and PE (18:0/22:6) in glycolytic muscle and that PGC-1alpha was required for these alterations. Because phospholipid fatty acid composition influences cell permeability and receptor stability at the cell membrane, these phospholipids may contribute to exercise training-mediated functional changes in the skeletal muscle. |
