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Comment :

Type  MGI:General Description  rare mutant ES cells that die following UV irradiation exhibit incomplete chromatin condensation rare mutant thymocytes that die following dexamethasone treatment show normal apoptotic features, including changes to phosphatidyl serine (PS) on the plasma membrane and chromatin condensation in contrast, mutant splenocytes that die in response to UV or gamma irradiation exhibit normal PS plasma membrane changes but aberrant chromatin condensation notably, caspase processing is inhibited in mutant ES cells but not in thymocytes or splenocytes