| First Author | Schnare M | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 10 | Pages | 947-50 |
| PubMed ID | 11547333 | Mgi Jnum | J:126395 |
| Mgi Id | MGI:3761205 | Doi | 10.1038/ni712 |
| Citation | Schnare M, et al. (2001) Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2(10):947-50 |
| abstractText | Mechanisms that control the activation of antigen-specific immune responses in vivo are poorly understood. It has been suggested that the initiation of adaptive immune responses is controlled by innate immune recognition. Mammalian Toll-like receptors play an essential role in innate immunity by recognizing conserved pathogen-associated molecular patterns and initiating the activation of NF-kappaB and other signaling pathways through the adapter protein, MyD88. Here we show that MyD88-deficient mice have a profound defect in the activation of antigen-specific T helper type 1 (TH1) but not TH2 immune responses. These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity. |
