| First Author | Koike MA | Year | 2011 |
| Journal | Neurosci Lett | Volume | 495 |
| Issue | 1 | Pages | 55-9 |
| PubMed ID | 21419194 | Mgi Jnum | J:172872 |
| Mgi Id | MGI:5009163 | Doi | 10.1016/j.neulet.2011.03.034 |
| Citation | Koike MA, et al. (2011) Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett 495(1):55-9 |
| abstractText | The risk of Alzheimer's disease increases following cerebral hypoperfusion. We studied the long-term interaction between low blood flow to the brain and Alzheimer's disease by inducing a transient global ischemic insult in aged 3xTg-AD mice and determining the effects on AD pathology 3-months post injury. We found that global ischemia does not increase the levels of amyloid-beta in these mice. However, the injury did lead to enhanced phosphorylation of the amyloid precursor protein (APP) at the Thr668 site in both the 3xTg-AD mice and wild-type controls. Furthermore, we found an increase in insoluble total tau 3-months post-injury. Together these findings further elucidate the long-term impact of cerebral hypoperfusion on Alzheimer's disease. |
