| First Author | Ahn GO | Year | 2008 |
| Journal | Cancer Cell | Volume | 13 |
| Issue | 3 | Pages | 193-205 |
| PubMed ID | 18328424 | Mgi Jnum | J:132946 |
| Mgi Id | MGI:3777223 | Doi | 10.1016/j.ccr.2007.11.032 |
| Citation | Ahn GO, et al. (2008) Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13(3):193-205 |
| abstractText | Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). By using a model system of transplanting tumors into an irradiated normal tissue to prevent angiogenesis, we found that tumors were unable to grow in matrix metalloproteinase-9 (MMP-9) knockout mice, but tumor growth could be restored by transplantation of wild-type BM. Endothelial progenitor cells did not contribute significantly to this process. Rather, CD11b-positive myelomonocytic cells from the transplanted BM were responsible for tumor growth and the development of immature blood vessels in MMP-9 knockout mice receiving wild-type BM. Our results suggest that MMP-9 could be an important target for adjunct therapy to enhance the response of tumors to radiotherapy. |
