| First Author | Ichikawa H | Year | 2000 |
| Journal | Neuroreport | Volume | 11 |
| Issue | 2 | Pages | 259-62 |
| PubMed ID | 10674466 | Mgi Jnum | J:60480 |
| Mgi Id | MGI:1353361 | Doi | 10.1097/00001756-200002070-00007 |
| Citation | Ichikawa H, et al. (2000) Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. Neuroreport 11(2):259-62 |
| abstractText | The distribution of S100-immunoreactive (ir) corpuscular endings was examined in the palate of wildtype and knockout mice for trkA, trkB or trkC. In wildtype mice, S100-ir corpuscular endings were abundant at the top of palatal rugae. The endings contained 2-4 parallel arrays of S100-ir neurites. The distribution of S100-ir nerve endings in trkA and trkC knockout mice was similar to that in wildtype mice; S100-ir corpuscular endings were abundant in palates of the mutant mice. In trkB knockout mice, the palate was devoid of corpuscular endings, An immunoelectron microscopic method indicated that S100-ir corpuscular endings were identical to Meissner corpuscles. The normal development of Meissner corpuscles is probably dependent on trkB but not trkA or trkC. |
