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Publication : Genomic and proteomic analysis of mammary tumors arising in transgenic mice.

First Author  Xie L Year  2005
Journal  J Proteome Res Volume  4
Issue  6 Pages  2088-98
PubMed ID  16335954 Mgi Jnum  J:106939
Mgi Id  MGI:3619793 Doi  10.1021/pr050214l
Citation  Xie L, et al. (2005) Genomic and proteomic analysis of mammary tumors arising in transgenic mice. J Proteome Res 4(6):2088-98
abstractText  Transforming growth factor-beta (TGF-beta) is the prototype of a large family of signaling molecules. TGF-beta signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-beta signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer.
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