| First Author | Cole N | Year | 2005 |
| Journal | Curr Eye Res | Volume | 30 |
| Issue | 7 | Pages | 535-42 |
| PubMed ID | 16020287 | Mgi Jnum | J:123047 |
| Mgi Id | MGI:3716277 | Doi | 10.1080/02713680590968583 |
| Citation | Cole N, et al. (2005) Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection. Curr Eye Res 30(7):535-42 |
| abstractText | PURPOSE: To determine the contribution of interleukin-4 (IL-4) to the initial host response during corneal infection with Pseudomonas aeruginosa in a mouse model. METHODS: Corneas of 6- to 8-week-old IL-4(-/-) and wild-type mice were topically challenged with P. aeruginosa. Ocular tissue was collected 24 hr and 7 days postchallenge. Viable bacterial counts, myeloperoxidase assays, cytokine levels, and clinical and histological examinations were performed. RESULTS: During challenge with P. aeruginosa, no differences were observed clinically, histologically, or in bacterial load between IL-4(-/-) and wild-type mice at either time point. However, differences in cytokine levels of IL-6, KC, and IL-10 were observed. CONCLUSIONS: The data presented indicate that IL-4, a central Th2 cytokine, may not be critical to the pathogenesis or bacterial clearance in this model of P. aeruginosa bacterial keratitis during the early stages of the infectious process. |
