Primary Identifier | MGI:5441845 | Allele Type | Targeted |
Attribute String | Modified regulatory region, Null/knockout | Gene | Rr20 |
Transmission | Germline | Strain of Origin | (129S6/SvEvTac x C57BL/6NTac)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The evolutionarily conserved candidate enhancer element (ECR5) that acts as a distal enhancer to Sost was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Immunohistochemistry confirmed highly variable expression of Sost. |