| Type | MGI:General | Description | in tamoxifen-treated mice, atomic force (AFM) and scanning electron microscopy (SEM) of tail tendon collagen I revealed swollen and distorted fibrils, lack of cohesion, crimping and disordered fibrils, unlike in control mice where normal D-banding and consistently regular and aligned fibrils are observed AFM showed a greater level of distortion with a far more irregular profile and height variation than in mice homozygous for Vipas39tm1c(KOMP)Mbp and heterozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj although the fibrillar D-banding period is not significantly altered, localized variations in the shape of the banding are observed, suggesting a disparity in quaternary collagen I structure |
