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Comment :

Type  MGI:General Description  at E8.0, the extraembryonic visceral endoderm shows wrinkled morphology, thickening of the visceral endoderm cell layer, and increased number and size of vesicular structures visceral endoderm cells are significantly enlarged and filled with large vesicular structures staining positive for glycoproteins in periodic acid-Schiff staining as well as for the lysosomal marker LAMP-1, indicating that accumulating vesicles are lysosomes