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Publication : Transcriptional control in the production of liver-specific mRNAs.

First Author  Derman E Year  1981
Journal  Cell Volume  23
Issue  3 Pages  731-9
PubMed ID  7226226 Mgi Jnum  J:25559
Mgi Id  MGI:73275 Doi  10.1016/0092-8674(81)90436-0
Citation  Derman E, et al. (1981) Transcriptional control in the production of liver-specific mRNAs. Cell 23(3):731-9
abstractText  cDNA clones complementary to liver mRNA were prepared and used to determine transcription rates of specific genes in isolated nuclei from liver, brain, and hepatoma cells. The cDNA sequences complementary to mRNA found only (or mainly) in the liver hybridize to labeled nuclear RNA only from liver nuclei. It appears that transcriptional events are primarily responsible for the synthesis of these, and perhaps most, tissue-specific moderately abundant mRNAs.
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