| First Author | Souza-Fonseca-Guimaraes F | Year | 2013 |
| Journal | Cancer Discov | Volume | 3 |
| Issue | 8 | Pages | 846-8 |
| PubMed ID | 23928773 | Mgi Jnum | J:204359 |
| Mgi Id | MGI:5532410 | Doi | 10.1158/2159-8290.CD-13-0271 |
| Citation | Souza-Fonseca-Guimaraes F, et al. (2013) Myeloid TGF-beta responsiveness promotes metastases. Cancer Discov 3(8):846-8 |
| abstractText | Tumor-induced immune suppression is a major impediment to many potentially effective cancer therapies. TGF-beta has previously been described as having both tumor-promoting and tumor-suppressive characteristics. In this issue of Cancer Discovery, Pang and colleagues show that myeloid-specific TGF-beta signaling is a critical mediator in tumor metastasis. These findings point to a more specific means to reduce cancer immunosuppression, prevent metastasis, and minimize treatment-related adverse events. |
