Primary Identifier | MGI:98419 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 109552 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription factor binding activity. Involved in negative regulation of cardiac muscle contraction; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within calcium ion transport. Located in Z disc; plasma membrane; and vesicle. Orthologous to human SRI (sorcin). PHENOTYPE: Mice homozgyous for a knock-out allele exhibit impaired glucose tolerance and decreased circulating insulin levels. [provided by MGI curators] |