| First Author | Zhang X | Year | 2007 |
| Journal | Cancer Lett | Volume | 253 |
| Issue | 1 | Pages | 53-9 |
| PubMed ID | 17321042 | Mgi Jnum | J:122435 |
| Mgi Id | MGI:3714410 | Doi | 10.1016/j.canlet.2007.01.009 |
| Citation | Zhang X, et al. (2007) Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice. Cancer Lett 253(1):53-9 |
| abstractText | The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P<0.05) decreased skin papilloma development during promotion phase. SD significantly (P<0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P<0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation. |
