First Author | Powers JM | Year | 1976 |
Journal | Arch Pathol Lab Med | Volume | 100 |
Issue | 2 | Pages | 69-73 |
PubMed ID | 946395 | Mgi Jnum | J:23525 |
Mgi Id | MGI:71274 | Citation | Powers JM, et al. (1976) Lack of amyloidosis and renal disease in A strain mice. Arch Pathol Lab Med 100(2):69-73 |
abstractText | Amyloid deposition in two sublines of the A strain mouse, a reputedly reliable murine model of spontaneous amyloidosis, was reevaluated using combined green polarization birefringence after Congo red staining and a fibrillar ultrastructure for amyloid identification. Both sublines were found to be devoid of amyloid at an age when the A strain mouse had been reported to have a high incidence of papillonephritis, amyloidosis, and death. This finding indicates a need for reassessment of this and other traditional models of spontaneous amyloidosis. |