| First Author | Jochum W | Year | 2001 |
| Journal | Oncogene | Volume | 20 |
| Issue | 19 | Pages | 2401-12 |
| PubMed ID | 11402336 | Mgi Jnum | J:69535 |
| Mgi Id | MGI:1934785 | Doi | 10.1038/sj.onc.1204389 |
| Citation | Jochum W, et al. (2001) AP-1 in mouse development and tumorigenesis. Oncogene 20(19):2401-12 |
| abstractText | Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles of AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis. |
