| First Author | Mizuno A | Year | 1998 |
| Journal | Gene | Volume | 215 |
| Issue | 2 | Pages | 339-43 |
| PubMed ID | 9714833 | Mgi Jnum | J:49549 |
| Mgi Id | MGI:1277686 | Doi | 10.1016/s0378-1119(98)00295-9 |
| Citation | Mizuno A, et al. (1998) Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis. Gene 215(2):339-43 |
| abstractText | Osteoclastogenesis inhibitory factor (OCIF) is a novel soluble-form member of the tumor necrosis factor receptor family and is involved in the regulation of bone mass. Here we isolated genomic and cDNA clones for mouse OCIF and determined their structures. Mouse OCIF gene spans 29 kb and contains five exons of 270, 367, 192, 225 and 1765 bp long. Four cysteine-rich domains and two death domain homologous regions characterized in human OCIF are rigidly conserved in mouse OCIF. The onset of OCIF gene expression in mouse embryogenesis is at day 8.5. In a pregnant female mouse, OCIF gene is expressed in decidua, a maternal tissue surrounding each embryo, immediately after implantation. The isolation of mouse OCIF gene should facilitate studies on OCIF knock-out mice for a better understanding of the role of OCIF in vivo. |
