| Primary Identifier | MGI:1335089 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14154 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of inflammatory response. Acts upstream of or within negative regulation of inflammatory response. Located in mitochondrion. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; retina; and spleen. Orthologous to human FEM1A (fem-1 homolog A). PHENOTYPE: Homozygous knockout results in an increased susceptibility to DSS-induced colitis and colitis-associated tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
