| First Author | Rauckhorst AJ | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 18 | Pages | 2367-71 |
| PubMed ID | 26206229 | Mgi Jnum | J:226333 |
| Mgi Id | MGI:5697102 | Doi | 10.1016/j.febslet.2015.07.016 |
| Citation | Rauckhorst AJ, et al. (2015) The iPLA(2)gamma is identified as the membrane potential sensitive phospholipase in liver mitochondria. FEBS Lett 589(18):2367-71 |
| abstractText | Previous reports from our lab identified a mitochondrial calcium-independent phospholipase A2 activity that is activated when the mitochondrial membrane potential is decreased. This activity was demonstrated to influence occurrence of the permeability transition. Originally, this activity was ascribed to the iPLA2beta protein. Recently, both iPLA2beta and iPLA2gamma knock out mice have been generated. It has been shown by others that the iPLA2gamma plays a significant role in progression of the permeability transition. In this paper, using the iPLA2beta and iPLA2gamma knock out mice we show that the membrane potential sensitive activity is the iPLA2gamma. |
