| First Author | Yamagata A | Year | 2015 |
| Journal | Sci Rep | Volume | 5 |
| Pages | 9686 | PubMed ID | 25989451 |
| Mgi Jnum | J:241468 | Mgi Id | MGI:5902672 |
| Doi | 10.1038/srep09686 | Citation | Yamagata A, et al. (2015) Structure of Slitrk2-PTPdelta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion. Sci Rep 5:9686 |
| abstractText | Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) delta. The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation. |
