Primary Identifier | MGI:5308943 | Allele Type | Targeted |
Attribute String | Not Specified | Gene | Ctnnb1 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A point mutation was introduced into exon 4 resulting in a D164A mutation and a floxed hygromycin cassette was inserted via homologous recombination. Homozygous mice show a strong reduction in Wnt/Beta catenin activity at E10. |