| Primary Identifier | MGI:2153072 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 68729 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables chromatin binding activity. Involved in negative regulation of gene expression, epigenetic. Predicted to be located in cytosol and peroxisome. Predicted to be part of ESC/E(Z) complex. Predicted to be active in aggresome and peroxisomal membrane. Is expressed in several structures, including epithelium; ganglia; genitourinary system; gut gland; and skin. Used to study mulibrey nanism. Human ortholog(s) of this gene implicated in mulibrey nanism. Orthologous to human TRIM37 (tripartite motif containing 37). PHENOTYPE: Mice homozygous for a knock-out allele are infertile due to gonadal degeneration and exhibit late-onset weight loss, smaller skull size, non-compaction cardiomyopathy, hepatomegaly, fatty liver, altered glucose metabolism, splenomegaly, and increased tumor incidence. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
