| First Author | Viennois E | Year | 2012 |
| Journal | Endocrinology | Volume | 153 |
| Issue | 7 | Pages | 3211-23 |
| PubMed ID | 22547570 | Mgi Jnum | J:188637 |
| Mgi Id | MGI:5441382 | Doi | 10.1210/en.2011-1996 |
| Citation | Viennois E, et al. (2012) Lxralpha regulates the androgen response in prostate epithelium. Endocrinology 153(7):3211-23 |
| abstractText | Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-alpha knockout mice (lxralpha(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted proteins in prostatic ducts and an alteration of vesicular trafficking in epithelial cells. In the fluid of the lxralpha(-/-) prostates, spermine binding protein is highly accumulated and shows a 3000-fold increase of its mRNA. This overexpression is mediated by androgen hypersensitivity in lxralpha(-/-) mice, restricted to the ventral prostate. Generation of chimeric recombinant prostates demonstrates that Lxralpha is involved in the establishment of the epithelial-mesenchymal interactions in the mouse prostate. Altogether these results point out the crucial role of Lxralpha in the homeostasis of the ventral prostate and suggest lxralpha(-/-) mice may be a good model to investigate the molecular mechanisms of benign prostatic hyperplasia. |
