| Primary Identifier | MGI:2384784 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 208643 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including ATP binding activity; eukaryotic initiation factor 4E binding activity; and nucleic acid binding activity. Acts upstream of or within behavioral fear response and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; heart; liver; and lung. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1). PHENOTYPE: Mice homozygous for an amino acid substitution (R1207H) are viable and fertile. Mice lacking the neuronal microexon exhibit social behavior abnormalities, learning and memory deficits, increased inhibitory synaptic conductance, and altered hippocampal synaptic plasticity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
