| First Author | Feil S | Year | 2004 |
| Journal | Circ Res | Volume | 94 |
| Issue | 7 | Pages | 863-5 |
| PubMed ID | 15044321 | Mgi Jnum | J:97558 |
| Mgi Id | MGI:3575841 | Doi | 10.1161/01.RES.0000126417.38728.F6 |
| Citation | Feil S, et al. (2004) SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Circ Res 94(7):863-5 |
| abstractText | The function of cytoskeletal proteins in the modulation of vascular smooth muscle cell (SMC) phenotype during vascular disease is poorly understood. In this report, we used a combination of gene targeting and Cre/lox-mediated cell fate mapping in mice to investigate the role of SM22alpha, an SMC-specific cytoskeletal protein of unknown function, in the development of atherosclerosis. In hypercholesterolemic ApoE-deficient mice, genetic ablation of SM22alpha resulted in increased atherosclerotic lesion area and a higher proportion of proliferating SMC-derived plaque cells. These results identify a role for SM22alpha in the regulation of SMC phenotype during atherogenesis. |
