| Primary Identifier | MGI:5295460 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence | Gene | Ptpn11 |
| Transmission | Germline | Strain of Origin | (129S6/SvEvTac x C57BL/6J)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 was replaced with a floxed neo/STOP cassette and a modified exon 3 in which nucleotide substitution (GAA to AAA) results in the amino acid substitution of lysine for glutamic acid at position 76 (E76K), mimicking a mutation found in some childhood acute leukemia and juvenile myelomonocytic leukemia (JMML) patients. This allele remains inactive until deletion of the neo cassette through cre-mediated recombination. |
