| First Author | Klose CS | Year | 2014 |
| Journal | Immunity | Volume | 41 |
| Issue | 2 | Pages | 230-43 |
| PubMed ID | 25148024 | Mgi Jnum | J:254632 |
| Mgi Id | MGI:6112349 | Doi | 10.1016/j.immuni.2014.06.018 |
| Citation | Klose CS, et al. (2014) The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8alphaalpha(+) intraepithelial lymphocyte development. Immunity 41(2):230-43 |
| abstractText | CD8alphaalpha(+) intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial barrier in the intestine. Similar to natural killer cells and other innate lymphoid cells, CD8alphaalpha(+) IELs constitutively express the T-box transcription factor T-bet. However, the precise role of T-bet for the differentiation or function of IELs is unknown. Here we show that mice genetically deficient for T-bet lacked both TCRalphabeta(+) and TCRgammadelta(+) CD8alphaalpha(+) IELs and thus are more susceptible to chemically induced colitis. Although T-bet was induced in thymic IEL precursors (IELPs) as a result of agonist selection and interleukin-15 (IL-15) receptor signaling, it was dispensable for the generation of IELPs. Subsequently, T-bet was required for the IL-15-dependent activation, differentiation, and expansion of IELPs in the periphery. Our study reveals a function of T-bet as a central transcriptional regulator linking agonist selection and IL-15 signaling with the emergence of CD8alphaalpha(+) IELs. |
