| Primary Identifier | MGI:7506448 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Sftpc |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The following elements were inserted immediately downstream of exon 1: coding cDNA sequence for exons 2-5 where exon 5 has a T-to-A point mutation changing leucine codon 184 to glutamine (p.L184Q), triple stop codons, bovine growth hormone gene poly(A) signal sequences and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation mimics the p.L188Q human mutation associated with lung disease. |
