| Primary Identifier | IPR012916 | Type | Domain |
| Short Name | RED_N |
| description | This domain contains sequences that are similar to the N-terminal region of Red protein (). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements []. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region [], suggesting that these proteins are expressed in the nucleus []. Protein RED (also known as IK) is found in the nucleus and is a component of the spliceosome []. It is also associated with the spindle pole where it co-localizes with and interacts with the spindle assembly checkpoint protein MAD1 during metaphase and anaphase. Depletion of RED shortens the mitotic cycle and MAD1 is incorrectly localized []. |
