| First Author | Wang H | Year | 2008 |
| Journal | Neuron | Volume | 59 |
| Issue | 4 | Pages | 634-47 |
| PubMed ID | 18760699 | Mgi Jnum | J:149875 |
| Mgi Id | MGI:3849269 | Doi | 10.1016/j.neuron.2008.06.027 |
| Citation | Wang H, et al. (2008) FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron 59(4):634-47 |
| abstractText | The fragile X mental retardation protein (FMRP) is an RNA-binding protein that controls translational efficiency and regulates synaptic plasticity. Here, we report that FMRP is involved in dopamine (DA) modulation of synaptic potentiation. AMPA glutamate receptor subtype 1 (GluR1) surface expression and phosphorylation in response to D1 receptor stimulation were reduced in cultured Fmr1(-/-) prefrontal cortex (PFC) neurons. Furthermore, D1 receptor signaling was impaired, accompanied by D1 receptor hyperphosphorylation at serine sites and subcellular redistribution of G protein-coupled receptor kinase 2 (GRK2) in both PFC and striatum of Fmr1(-/-) mice. FMRP interacted with GRK2, and pharmacological inhibition of GRK2 rescued D1 receptor signaling in Fmr1(-/-) neurons. Finally, D1 receptor agonist partially rescued hyperactivity and enhanced the motor function of Fmr1(-/-) mice. Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome. |
