| Primary Identifier | MGI:2384933 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 216853 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including identical protein binding activity; telomerase RNA binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including RNA localization to Cajal body; positive regulation of double-strand break repair; and telomere organization. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol; nuclear body; and site of double-strand break. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in Cajal body. Is expressed in palatal shelf. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). PHENOTYPE: Mice homozygous for a knock-out allele exhibit defects in chorion formation and placentation, abnormal trophoblast layer morphology, and complete embryonic lethality during organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
