| First Author | Melichar HJ | Year | 2007 |
| Journal | Science | Volume | 315 |
| Issue | 5809 | Pages | 230-3 |
| PubMed ID | 17218525 | Mgi Jnum | J:117301 |
| Mgi Id | MGI:3695974 | Doi | 10.1126/science.1135344 |
| Citation | Melichar HJ, et al. (2007) Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science 315(5809):230-3 |
| abstractText | alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes. |
