| First Author | Hioki K | Year | 2001 |
| Journal | Exp Anim | Volume | 50 |
| Issue | 1 | Pages | 67-72 |
| PubMed ID | 11326425 | Mgi Jnum | J:68089 |
| Mgi Id | MGI:1932030 | Doi | 10.1538/expanim.50.67 |
| Citation | Hioki K, et al. (2001) Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice. Exp Anim 50(1):67-72 |
| abstractText | BALB/cA mice homozygous for both nu and scid mutations (BALB/cA-nu/nu, scid/scid) were developed by mating between BALB/cA-scid and BALB/cA-nu. These mice have greater longevity than C.B-17-scid because no thymic lymphoma occurs in them unlike in the latter. C.B-17-scid is known to show the leaky phenomenon in which a few clones of functional T and B cells develop in aged C.B-17-scid. Unexpectedly, the leaky B cells and T cells were absent or suppressed in BALB/cA-nu, scid mice when cytokine expressions were determined by RT-PCR, lymphocyte phenotypes by flow cytometry and serum immunoglobulin levels by ELISA. These results indicate that B cell leakiness may be induced by leaked T cells. BALB/cA-nu, scid mice may be useful as a recipient in allo- and xeno-transplantation experiments because of the absence of both thymic lymphomas and leakiness, in addition to lack of hair. |
