| First Author | Kang H | Year | 2001 |
| Journal | Cell | Volume | 106 |
| Issue | 6 | Pages | 771-83 |
| PubMed ID | 11572782 | Mgi Jnum | J:71846 |
| Mgi Id | MGI:2150877 | Doi | 10.1016/s0092-8674(01)00497-4 |
| Citation | Kang H, et al. (2001) An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell 106(6):771-83 |
| abstractText | Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory. |
