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Publication : miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions.

First Author  Hsu SD Year  2014
Journal  Nucleic Acids Res Volume  42
Issue  Database issue Pages  D78-85
PubMed ID  24304892 Mgi Jnum  J:207957
Mgi Id  MGI:5559992 Doi  10.1093/nar/gkt1266
Citation  Hsu SD, et al. (2014) miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions. Nucleic Acids Res 42(Database issue):D78-85
abstractText  MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
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